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Methyl Charge GF V


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Q1148 50 ml $30.00 Add To Cart
Methyl Charge+TM is a promethylation liposomal formula that includes vitamins B2, methyl-B12, trimethylglycine (TMG or betaine), B6 and folinic acid. Methyl Charge+TM represents a second generation methylation formulation, focusing on the catalytic activity of methyltranferases, a large class of important enzymes that broadly catalyze the transfer of methyl groups and thus modify DNA and gene expression. First generation methylation supplements focused solely on raising 5-MTHF (L-5- methyltetrahydrofolate), the naturally-occurring, active form of folic acid, to counter methylation issues arising from variations in the MTHFR gene (methylenetetrahydrofolate reductase). While this new formulation can be a stand-alone supplement to safely increase methylation dynamics in hypomethylators, it was originally developed to pair with our NAD+ GoldTM product. Methylation is critical to detoxification, glutathione regeneration1, and DNA repair, but early approaches to methylation ignored the vital connection of methylation cycles to the NAD+ cycle (see image below). In fact, supplementation with any compounds in the vitamin B3 family was intentionally avoided, as these NAD+ precursors were thought at the time to act as “methyl sponges”. Unfortunately, imbalanced supplementation with only pro-methylation compounds often yielded short-term benefits which gave way to a “crash” that is now understood to be mitochondrial dysfunction downstream of NAD+ deficiency.2
Supplement Facts
Supplement Facts
50 Servings
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. If pregnant, consult a physician before use.

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